Computational Model for Targeted Drug Delivery by Magnetic Nanoparticles

Document Type : Research Paper

Authors

1 student/Plasma Physics Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran

2 Member of Physical Department/Plasma Physics Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran

Abstract

In this article, the use of magnetic nanoparticles as transport agents in various biological programs is investigated and a magnetic process is analyzed in which magnetic carrier particles are guided to an object by an external magnetic field for drug delivery to the target. In addition, the paths of magnetic nanoparticles are simulated using the COMSOL software. In order to accumulate the drug at tumor sites and to prevent its undesirable side effects on healthy cells, the drug needs to be targeted merely to lesion sites. Therefore, nanoparticles are used for targeted drug delivery to the tumor cells. Among these, several factors influence the movement of nanoparticles. The direction of particles is affected by strength of the magnetic field, the shape of the magnet, the size and the magnetic properties of the nanoparticles. The external magnetic field can be generated in several ways, which in this research we have simulated a magnetic field generated by two special magnets.

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References

[1] Strebhardt, K. and Ullrich A., “Paul Ehrlich's magic bullet concept: 100 years of progress”, Nature Reviews Cancer, 2008, 8(6): p. 473-480.
[2] Furlani E. P., “A Model for Predicting Magnetic Targeting of Multifunctional Particles in the Microvasculature”, (2007).4-5.
[3] Kayal S., Bandyopadhyay D., Mandal T. K. and Ramanujan R. V., “The flow of magnetic nanoparticles in magnetic drug targeting”, (2011)238-246.
 [4] Liu Y., Shah S. and Tan J., “Computational Modeling of Nanoparticle Targeted Drug Delivery”, (2012).66-67.

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History

  • Receive Date: 07 March 2019
  • Revise Date: 10 September 2019
  • Accept Date: 08 February 2020

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