مقالۀ پژوهشی: مدل‌سازی ریاضی بیان ژن: رهیافت آشوب

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشجوی دکتری، گروه فیزیک، دانشگاه صنعتی ارومیه، ارومیه، ایران

2 استاد، گروه فیزیک، دانشگاه صنعتی ارومیه، ارومیه، ایران

چکیده

ژن یک عامل کد کننده اطلاعات ژنتیکی و واحد اصلی وراثت است. بیان ژن پدیده ای است که از دو مرحله پیچیده رونویسی و ترجمه تشکیل شده است. در این مطالعه، با توجه به اهمیت پدیده بیان ژن، به بررسی تحول سلول مخمر ساکارومایسس سرویزیه پرداخته شده است. برای روشن شدن صحت نتایج به‌دست‌آمده، از داده‌های تجربی روی سلول مخمر ساکارومایسس سرویزیه از بانک ژن استفاده کرده‌ ایم. ما از نظریه آشوب برای مطالعه بیان ژن به دلیل دینامیک غیرخطی این پدیده استفاده می کنیم. نتایج به‌دست‌آمده پیش‌بینی می‌کند که با افزایش میزان تخریب در نرخ آرنای پیام‌رسان به 0.03، به مقدار آستانه برای پدیده بیان ژن رسیده‌ایم. همچنین، ما تشخیص داده‌ایم که افزایش رونویسی با افزایش نرخ تخریب آرنای پیام‌رسان مرتبط است. مقدار بهینه نرخ تاخیر رونویسی ( 18.2 دقیقه ) و مقدار نرخ تخریب پروتئین (0.03) به دست آمد. تطابق خوبی بین نتایج تجربی و نظری وجود داشت.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

Research Paper: Mathematical modeling of gene expression: chaos approach

نویسندگان [English]

  • Fatemeh Nemati 1
  • Sohrab Behnia 2
1 PhD Student, Department of Physics, Urmia University of Technology, Urmia, Iran
2 Professor, Department of Physics, Urmia University of Technology, Urmia, Iran
چکیده [English]

Gene is a factor encoding genetic information and the basic unit of inheritance. Gene expression is a phenomenon consisting of two complex stages of transcription and translation. In this study, the yeast cell of Saccharomyces cerevisiae evolution is investigated due to the importance of the gene expression phenomenon. To clarify the accuracy of the obtained results, we have used experimental data on the Saccharomyces cerevisiae yeast cell from the gene bank. We are using chaos theory to study gene expression due to the nonlinear dynamics of the phenomenon. The obtained results predict that, by increasing the rate of degradation in the messenger arena to 0.03, we have reached the threshold value for the gene expression phenomenon. Also, we have recognized that increased transcription is associated with an increased mRNA degradation rate. The optimal values of transcription delay rate (18.2 min) and protein degradation rate (0.03) were obtained. There was a good agreement between the experimental and theoretical results.

کلیدواژه‌ها [English]

  • Gene expression
  • Nonlinear dynamics
  • Chaos approach
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